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ORIGINAL ARTICLE
Year : 2020  |  Volume : 9  |  Issue : 1  |  Page : 17

Evaluation of the bactericidal activity of some disinfectant agents against carbapenem-resistant Klebsiella pneumoniae isolates


1 Department of Medical Microbiology, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde, Turkey
2 Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gazi University, Ankara, Turkey
3 Department of Medical Microbiology, Faculty of Medicine, Yüksek İhtisas University, Ankara, Turkey
4 Department of Medical Microbiology, Faculty of Medicine, SANKO University, Gaziantep, Turkey
5 Department of General Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey
6 Department of Medical Microbiology, Faculty of Medicine, Gazi University, Ankara, Turkey

Correspondence Address:
Ali Ozturk
Department of Medical Microbiology, Faculty of Medicine, Nigde Omer Halisdemir University, 51240 Nigde
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijehe.ijehe_15_20

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Aim: This study is aimed to determine the disinfectant activity of Derdevice plus Y® and I&D Sept® against carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates. Materials and Methods: The bactericidal activity of Derdevice plus Y® and I&D Sept® were tested in vitro under clean and dirty conditions by a quantitative suspension test according to EN 13727. The effectiveness of the disinfectants was compared with 10% sodium hypochlorite (NaOCl), 7% benzalkonium chloride (BC), 2% chlorhexidine digluconate (CHX), and 70% ethyl alcohol (EtOH). After 1, 5, and 60 min of contact with the biocides, the colony-forming units were counted, and the logarithmic reduction factor was determined. Results: A dilution of 1/300 of Derdevice plus Y® disinfectant showed bactericidal activity against clinical isolates and standard strains (growth reduction was =5 log10) after 5 and 60 min contact times and under clean and dirty conditions. A 100% concentration of I&D Sept® showed a bactericidal effect within the contact time (60 min) under clean and dirty conditions with the reductions of =5 log10 and =3 log10, respectively. Standard biocides such as BC, CHX, NaOCl, and EtOH showed marked effects after various contact times and the conditions onto tested strains. Conclusions: The results of our study confirm that the biocides of Derdevice plus Y® and I&D Sept® used in our hospital were found to be effective against K. pneumoniae isolates.


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